The Abii Platform
Three technical innovations working together to deliver sequence-defined, format-flexible recombinant antibodies.
How Abii Antibodies Work
Conventionally, every antibody format is a separate product, with its own development, its own batch history and its own validation. Abii treats the binder as a permanent asset and the constant region as a configurable parameter.
Sequence-Defined Production
Every antibody is produced from a propietary genetic platform. No hybridoma or animal-derived step. The identity of each antibody is fixed at the DNA level, same construct, same antibody, batch after batch.
Modular Constant Region
Abii's constructs separate the variable domains from the constant region. Swapping the Fc redefines the species, isotype and effector profile of the antibody, and with them how it is detected and how it behaves in your system, while the paratope and the VH-VL interface stay untouched.
Proprietary Expression System
A proprietary expression architecture drives coordinated production of the heavy and light chains from a single modular construct, enabling efficient and reproducible antibody assembly.
Same Binder, Three Species Formats, One EC50
Independent published work reformatted a single antibody into human, rabbit and pig IgG. The three versions bind the antigen with the same affinity within a narrow margin. This is the premise the Abii platform is built on.
Fig 1D from Bhatti MM, Cai AG, Theunissen J-W (2019), Binding affinities of human IgG1 and chimerized pig and rabbit derivatives to human, pig and rabbit Fc gamma receptor IIIA, PLOS ONE 14(7): e0219999, doi.org/10.1371/journal.pone.0219999, licensed under CC BY 4.0. Recoloured by Abii for legibility; the data are unchanged. Independent published work, not Abii data.
How a Project Runs
You bring the target. Each phase is a checkpoint, and you commit to one at a time.
Identify the binder
No commercial antibody for your target? We find a usable binder and verify it.
Antigen expression
We express your antigen recombinantly and confirm its identity before anything scales.
Standard formats
Your binder delivered in the formats most labs use, from stable production.
Custom formats
Effector-tuned and multivalent variants, built on the same binder on request.
If a binder does not express well or does not recognise its target, the program stops there, so your commitment always matches what is actually working.
Interested in our antibodies?
Tell us your target antigen and the formats you need. We will get back to you with a proposal.
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